Genesis Two - Euphrates River

"Now a river went out of Eden to water the garden, and from there it parted and became four riverheads. The name of the first is Pishon; it is the one which skirts the whole land of Havilah, where there is gold. And the gold of that land is good. Bdellium and the onyx stone are there. The name of the second river is Gihon; it is the one which goes around the whole land of Cush. The name of the third river is Hiddekel; it is the one which goes toward the east of Assyria. The fourth river is the Euphrates," Genesis 2:10-14, NKJV. #EuphratesRiver
The Euphrates River is the only surviving flowing body of water from the Garden of Eden (besides an indirect reference to the River of Life), mentioned in scripture from Genesis to Revelation; it is the eastern most border of the nation that circled the Mediterranean to the west, the Nile and the Arabian Peninsula to the south, to the Black Sea in the north, encompassing the area where most of the activity in the bible takes place.
Deuteronomy 1:7, 2 Kings 24:7 and Revelation 16:12-16.